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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
41.52
Human Site:
Y676
Identified Species:
70.26
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
Y676
E
H
P
L
A
Q
L
Y
C
H
S
I
M
E
H
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
Y676
E
H
P
L
A
Q
L
Y
C
H
S
I
M
E
H
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
Y676
E
H
P
L
A
Q
L
Y
C
H
S
I
M
E
H
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
Y666
E
H
P
L
A
Q
L
Y
C
H
S
I
M
E
H
Rat
Rattus norvegicus
O54735
833
94538
Y634
E
H
P
L
A
Q
L
Y
C
H
S
T
M
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
Y664
D
H
P
L
A
Q
L
Y
C
H
S
I
M
E
H
Chicken
Gallus gallus
P52731
862
99990
H625
A
A
P
L
A
K
L
H
G
S
S
I
L
E
R
Frog
Xenopus laevis
NP_001088271
859
97399
Y656
E
H
P
L
A
Q
L
Y
C
H
S
I
M
E
N
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
Y662
D
H
P
L
A
Q
L
Y
C
H
S
T
M
E
H
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y681
G
S
A
L
S
L
L
Y
G
T
S
A
T
L
E
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
Y923
S
S
P
L
A
Q
L
Y
S
T
S
T
M
E
H
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y729
E
S
P
L
A
I
L
Y
S
T
S
T
M
E
H
Nematode Worm
Caenorhab. elegans
P91119
710
81117
M551
S
I
Y
S
T
S
V
M
E
R
H
H
F
N
Q
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y681
S
S
P
L
S
L
L
Y
G
T
S
T
M
E
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
93.3
N.A.
93.3
46.6
93.3
86.6
26.6
66.6
66.6
0
53.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
93.3
N.A.
100
66.6
100
93.3
33.3
66.6
66.6
6.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
79
0
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
58
0
0
0
0
0
0
% C
% Asp:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
50
0
0
0
0
0
0
0
8
0
0
0
0
86
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
22
0
0
0
0
0
0
% G
% His:
0
58
0
0
0
0
0
8
0
58
8
8
0
0
72
% H
% Ile:
0
8
0
0
0
8
0
0
0
0
0
50
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
93
0
15
93
0
0
0
0
0
8
8
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
79
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% N
% Pro:
0
0
86
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
65
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
22
29
0
8
15
8
0
0
15
8
93
0
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
29
0
36
8
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
86
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _